MD REVIEW

Semaglutide Halves Diabetes Obesity Risk

Mitchel L. Zoler, PhD
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Treatment of people with obesity but without diabetes using the glucagon-like peptide-1 (GLP-1) agonist semaglutide (Wegovy) led to beneficial changes in body mass index (BMI), glycemic control, and other clinical measures.

This collectively cut the calculated risk for possible future development of type 2 diabetes in study participants by more than half, based on post-hoc analysis of data from two pivotal trials that compared semaglutide with placebo.

The findings “suggest that semaglutide could help prevent type 2 diabetes in people with overweight or obesity,” said W. Timothy Garvey, MD, in a presentation at the European Association for the Study of Diabetes 2022 Annual Meeting.

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