Immunology

HIV and AIDS Remain Serious

Seriousness of HIV and AIDS

First identified among the homo­sexual community in 1981, by the 1990s HIV became a threat to any sexually active individual. What is today’s outlook?

Global Infection Continues

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Long before the coronavirus pandemic, HIV and AIDS over­whelmed the world. HIV was first identified among the homo­sexual (now LGBTQ+) community in 1981. By the 1990s AIDS became a popular threat for hetero­sexual indivi­duals. More than 70 million people have been infected. According to the World Health Organization (WHO), half as many have died from AIDS since that pandemic began.

We must wait to see if COVID-19 will approach a similar magnitude. Currently, AIDS has claimed far more victims, and remains active, though it is manageable with drugs. [1]

The human immunodeficiency virus (HIV) is the precursor to acquired immuno­deficiency syndrome (AIDS). Any virus that compromises the immune system is dangerous. This is our internal defense mechanism that tries to eliminate foreign invaders.

The virus is transmit­ted through bodily fluids such as blood (open sores or shared needles), semen, vaginal fluids, anal secretions, and breast milk. The risk increases for the receptive sex partner, with anal sex having the highest transmis­sion rates. [2,3]

Acute Stage-1 HIV Symptoms

The only way to know for sure if you have HIV is to get tested. Within 2 to 4 weeks after infection with HIV, about two-thirds of people will have a flu-like illness. This is the body’s natural response to HIV infection. [3,4] Flu-like HIV symptoms can include:

  • Fever
  • Chills
  • Fatigue
  • Night sweats
  • Muscle aches
  • Sore throat
  • Swollen lymph nodes
  • Mouth ulcers
  • Rash

      During stage 2, the virus multiplies at very low levels. It is important to see your healthcare provider regularly to get your viral load and CD4 checked.

      Stage-3 AIDS Symptoms

      If you are not receiving treatment for HIV, eventually the virus will weaken your body’s immune system. Then you will progress to the next step, which is AIDS. This is the late stage of HIV infection. [4,5] Symptoms of AIDS can include:

      • Rapid weight loss
      • Recurring fever or profuse night sweats
      • Extreme and unexplained tiredness
      • Prolonged swelling of the lymph glands in the armpits, groin, or neck
      • Diarrhea that lasts for more than a week
      • Sores of the mouth, anus, or genitals (genitalia)
      • Pneumonia
      • Red, brown, pink, or purplish blotches on or under the skin or inside the mouth, nose, or eyelids
      • Memory loss, depression, and other neurologic disorders

      Treatment

      Currently, there is still no cure for HIV or AIDS. There are medica­tions to weaken the virus and slow the spread throughout our body. Without medica­tion, AIDS life expectancy is 1–3 years. Early anti­retroviral therapy treat­ment can extend life nearly as long as someone with­out the virus. [5] Doctors consider HIV as progres­sing to AIDS when either:

      1. The number of CD4 cells falls below 200 cells per cubic millimeter of blood (200 cells/mm3). (In someone with a healthy immune system, CD4 counts are between 500 and 1,600 cells/mm3.) [6]
      2. A patient develops one or more opportunistic infections regardless of their CD4 count.

        Since proper treatment affects mortality, early diagnosis is para­mount for anyone sexually active. Self-testing allows people to get tested for HIV while still following stay-at-home orders and social distancing practices. Ask your local health department or HIV service organiza­tion if they offer self-testing kits.

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        To support the writing of useful articles about immunology, ClinicalPosters sells human anatomy charts, scientific posters, and other products online. You may sponsor specific articles or remit a small donation.

        ClinicalPosters sells human anatomy charts, scientific posters, and other products online to offset expense of the writing useful articles about immunology. Slide extra posters into DeuPair Frames without removing from the wall.

        ClinicalPosters sells human anatomy charts, scientific posters, and other products online. You may remit a small donation.

        You can support the writing of useful articles about immunology by sponsoring specific articles or remitting a small donation. Visible content is optimized for device size.

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