Depressants, Stimulants and Hallucinogens

Effects of Drugs on Weight Change

Depressants

Depressants refer to substances that can slow normal processes in the body and reduce physical activity by altering the manner in which the brain sends and receives signals. Alcohol, marijuana (cannabis) and opiates such as morphine, codeine, heroin, methadone, hydrocodone (e.g. Lortab, Norco) and oxycodone (e.g. OxyContin) are all categorized here as depressants.

Opiates

Codeine, morphine, methadone, Hydrocodone and OxyContin are all opiates that can be prescribed by a physician to treat intense pain or certain painful conditions (e.g., cancer). Methadone is even prescribed for some people who are addicted to heroin in order to help them overcome their opiate dependence or addiction [1].

Dependence occurs when the body builds up a tolerance to an opiate and an individual’s dose has to be increased in order to experience an effect. If the person abruptly stops taking the opiate, serious withdrawal symptoms may be experienced. To mitigate this uncomfortable period of withdrawal, people frequently undergo medically supervised detoxification as an initial step of substance abuse treatment.

Effects of Drugs and Alcohol on Weight

Addiction can develop when high doses of an opiate are consumed for an extended period — causing changes in the brain that can result in compulsive cravings and can elicit drug-seeking behavior regardless of the negative effects that the addiction has on a person’s life and health.

Although opiates are commonly prescribed to treat pain, their use can quickly translate to misuse due to the sense of euphoria that people tend to experience after taking this type of drug. It is this feeling of euphoria that generally leads to opiate dependence and addiction in many people [2].

To varying degrees, the narcotic analgesics in the opiate class can cause side effects that include:

  • Drowsiness
  • Nausea
  • Vomiting
  • Constipation

Side effects such as these can lead to a decrease in appetite, slowed digestion and weight loss, over time. In addition, opiate dependence and, especially, addiction can often result in dramatic weight loss when people begin to engage in drug seeking behavior more often than eating properly.

Heroin

Effects of Drugs and Alcohol on Weight

Heroin is a particularly dangerous opiate that is highly addictive. It is usually purchased on the street as opposed to abused prescription opiates. Similar to other drugs in this class, its users may display erratic drug seeking behavior, altered eating habits and weight loss if it is taken regularly [3].

Heroin abusers may experience a brief period of euphoria that is followed by confusion and drowsiness. Prolonged use, and the subsequent repeated cycle of euphoria/drowsiness results in the development of irregular eating habits or forgetting to eat altogether. Long-term opiate abuse also leads to extensive organ damage and disease, which is typically associated with weight loss.

Marijuana

Effects of Drugs and Alcohol on Weight

Marijuana, as a recreational drug, is among the most commonly used depressants by adolescents [4]. Excessive marijuana use alters mental processes such as memory and thinking. Most people experience short-term memory problems that may become permanent if a prolonged period of drug abuse starts. Memory problems may result in dietary changes and weight loss. However, a number of individuals who take marijuana experience a subjective increase in appetite that is frequently referred to as the munchies. This may cause overeating and weight gain.

Concentration, hand and eye coordination and reasoning problems may also develop due to marijuana use and this may make it difficult for people to maintain a healthy diet. Long-term problems that may arise from marijuana use include depression and organ damage, especially if marijuana is taken with alcohol. These types of health problems are often associated with fluctuations in weight.

Stimulants

Drugs with stimulant effects — caffeine, ecstasy (MDMA), cocaine and methamphetamines (e.g., speed or crystal meth) among this list — can speed up brain activity, and have the potential to increase blood pressure and heart rate. Stimulants can alter certain mental processes, with people often failing to recognize the homeostatic urges of hunger or dehydration. When stimulants are abused, this effect could result in weight loss and other, more lethal health consequences.

Ecstasy (MDMA)

Ecstasy is a commonly taken illicit drug that is typically sold on the streets. A serious problem that is associated with the purchase of ecstasy involves not knowing whether the drug is made up of a pure product or a combination of other harmful substances. Commonly reported adulterant substances include amphetamine, ephedrine and over-the-counter cold remedies such as pseudoephedrine and dextromethorphan (DXM).

Taking just one dose of ecstasy can cause harmful side effects such as [5]:

  • Anxiety, paranoia or depression
  • Memory and sleep disturbances
  • A rapid, slow or irregular heartbeat, which may result in death
  • A rapid loss of sodium (salt) in the blood, which can negatively impact normal functions in the body
Effects of Drugs and Alcohol on Weight

The long-term abuse of ecstasy may result in serious muscle tissue damage and the release of muscle enzymes into the blood. These large proteins can deposit in the kidneys, leading to damage or overt renal failure.

Stimulants such as ecstasy often make people feel as if they have high levels of energy and this may prevent them from realizing that they are hungry or have not been drinking enough liquids. Long-term use may result in weight loss. The relatively long acting effects of ecstasy can elevate body temperature, and an accompanying state of dehydration can become quite serious, if not fatal. As with other psychoactive drugs, changes in mental processes can a host of negative influences on a healthy body weight, especially abused for long periods of time.

Cocaine

Cocaine is a highly addictive stimulant that increases blood pressure, suppresses the appetite and can cause regular users to eat fewer balanced meals than those who do not use cocaine [6]. Cocaine abuse also inhibits the ability to gauge the amount of fatty foods that are being eaten when feelings of hunger become dire [6].

Effects of Drugs and Alcohol on Weight

Side effects such as these lead to irregular eating patterns and weight loss. Drug seeking behavior, which commonly occurs due to cocaine abuse, can also reduce the appetite thereby causing individuals to forget to eat properly and eventually begin to lose weight. The cessation of prolonged cocaine use leads to an increase in appetite and subsequent weight gain in some individuals.

Methamphetamine

Methamphetamines (speed, crystal meth, meth) share a number of effect on the mind and body with ecstasy, especially in regard to decreases in appetite and memory function. Of note, long term abuse of amphetamines may cause a syndrome of depression as well. Each of these side effects may result in unhealthy eating habits, weight loss and, secondarily to depression, even weight gain over time. Similar to cocaine cessation, the cessation of methamphetamines after a prolonged period of abuse has, in some cases, lead to a rebound appetite increase with resultant weight gain.

Hallucinogens

Hallucinogens dramatically alter the mind and the senses by causing people to experience a variety of sensory hallucinations — often seeing distorted images or objects that are not really there. These types of hallucinations often occur in conjunction with markedly abnormal behavior, anxiety attacks and paranoia.

Effects of Drugs and Alcohol on Weight

PCP, LSD, ketamine and magic mushrooms all have the potential to elicit hallucinations or powerful dissociative experiences. People who take large amounts of ecstasy or marijuana may also report episodes of hallucination.

Hallucinogens can affect emotions, concentration, memory and thinking ability, as well as cause distorted vision and hearing. Drowsiness, sweating, nausea, vomiting and irregular breathing may also occur [7]. This array of issues, particularly in those who abuse them long-term, can lead to loss of appetite and diminished nutrition and, over time, contribute to unhealthy weight loss.

The Dangers of Mixing Drugs

People who begin to take drugs regularly or experiment with drugs may begin to mix them or combine them with alcohol. Mixing drugs with other drugs or alcohol compounds the individual risks inherent to each substance — risks like breathing problems, nausea, vomiting, vertigo, syncope (fainting), abnormal or dangerous behavior and ultimately, the risk of overdosing or dying.

Overall, drug abuse alters the mind and body in ways that make it almost impossible to maintain a healthy diet. Poor nutrition leads to serious health problems, and many diseases that may develop secondarily due to drug abuse also have associated weight changes.

Potential long-term effects of substance abuse

Dramatic weight loss due to substance abuse increases the risk of suffering from low blood sugar, heart arrhythmias, electrolyte and mineral imbalances, gallstones and alterations in blood pressure. Health problems such as these can become long-term and life-threatening.

Effects of Drugs and Alcohol on Weight

Dangerously low blood sugar levels may lead to dizziness, confusion, tremors, trouble speaking or coma, while untreated heart arrhythmias may result in death. If the heart begins to beat too rapidly, a side effect of certain stimulants such as cocaine and methamphetamines, the heart may go into sudden cardiac arrest. Even if an individual is resuscitated, major organs may become seriously damaged due to cardiac arrest [8].

Losing significant amounts of weight may also result in unhealthy overeating to circumvent feelings of hunger or distress regarding the weight loss. Repeated starvation, which may result due to drug seeking behavior and other changes in mental processes that often occur concurrently with substance abuse, leads to the release of neurotransmitters that allow people to eat well beyond the satiation point by overriding their feelings of hunger.

High blood pressure, type 2 diabetes, heart disease, sleep apnea, kidney disease, respiratory problems, cancer and osteoarthritis are among the many long-term health problems that may develop due to weight gain that is concurrent with substance abuse [8].

In general, the abuse of recreational, illicit, and prescription drugs can all result in similarly disastrous long-term effects on health — with dramatic vacillations in body weight, both up and down.

The Importance of Substance Abuse Treatment

Although various types of effective treatments have been established for substance abuse, it remains one of the leading causes of emergency room visits and death. This, in part, appears to be because people tend to avoid seeking treatment for at least 10 years after their substance abuse has started [9]. Due to this mismatch between available treatment, and the people who are in desperate need of it, substance abuse continues to be a major public health issue.

In addition to causing harmful fluctuations in weight, substance abuse can lead to multiple major organ damage, especially to the kidneys and heart [10,11]. People who have health problems such as arthritis or diabetes tend to worsen their symptoms and even speed up the progression of their condition through drug abuse, with any associated weight changes potentially compounding the damage done.

Chronic substance abusers should be mindful of the painful, debilitating and, in some cases, life-threatening withdrawal symptoms that may develop when the drugs and/or alcohol are stopped. While not an exhaustive list, a withdrawal syndrome can encompass: heavy sweating, pain throughout the body, fever, nausea, vomiting, diarrhea and intense cravings. Even relatively mild symptoms such as these can make it quite difficult for people to overcome their substance abuse without the guidance of medical and treatment professionals. On a more serious end of the spectrum, acute alcohol and benzodiazepine withdrawal can result in dangerous seizures and even death. For these and a number of other reasons, it is in one’s best interest to seek professional assistance for the treatment of alcohol and substance abuse in order to prevent or address serious health problems, and to help guarantee a positive course of recovery.

About The Author
Karen Vieira

Dr. Karen Vieira, PhD MSM is a research scientist with a PhD in Biomedical Sciences from the University of Florida College of Medicine Department of Biochemistry & Molecular Biology. She has done clinical and laboratory research on diseases, cellular functioning and nutritional supplements. Her focus is helping people make dietary and lifestyle changes that prevent, cure or improve health conditions.

Tags: doctors, nurses, nutritionists, rehabilitation

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